Resumen:
izoxanide [2-(hydroxy)-N-(5-nitro-2-thiazolyl)benzamide, TIZ] is a new potent anti-infective agent
which may enhance current therapies for leishmaniasis, Chagas disease and viral hepatitis. The aim of
this study was to identify the conformational preferences that may be related to the biological activity
of TIZ by resolving its crystal structure and characterizing various physicochemical properties, including
its experimental vibrational and 13C nuclear magnetic resonance properties, behavior on heating and solubility
in several solvents at 25 C. TIZ crystallizes from dimethylformamide as the carboxamide tautomer
in the triclinic system, space group P(1) (No. 2) with the following unit cell parameters at
173(2) K: a = 5.4110(3) Å, b = 7.3315(6) Å, c = 13.5293(9) Å, a = 97.528(3), b = 95.390(4), c = 97.316(5),
V = 524.41(6) Å3, Z = 2, Dc = 1.680 g/cm3, R1 = 0.0482 and wR2 = 0.0911 for 2374 reflections. This modification
of TIZ has a ‘graphitic’ structure and is composed of tig