The crystal structure and physicochemical characteristics of 2-Hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine, a new anti-Trypanosoma cruzi drug

AAPS PHARMSCI TECH.

Springer

Año: 2005 vol. 6 p. 655 - 655

font size="3" face="AdvTT3713a231"> This study was designed to investigate the physical characteristics and crystalline structure of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine (PNQ), a new active compound against Trypanosoma cruzi, the causative  agent of American trypanosomiasis. Methods used included differential scanning calorimetry, thermogravimetry, hot stage microscopy, polarized light microscopy (PLM), Fourier-transform infrared (FTIR) spectroscopy, and high resolution X-ray powder diffraction (HR-XRPD). According to PLM and HR-XRPD data, PNQ crystallized as red oolitic crystals (absolute m