Antibiotic activity of isoxazolylnaphthoquinones on mice infected with Staphylococcus aureus".

NR SPERANDEO

JOURNAL OF APPLIED BACTERIOLOGY

Blackwell Publishing

Año: 1995 vol. 78 p. 373 - 373

0021-8847

heantibiotic activity of new synthetic isoxazolylnaphthoquinone imines was studied.Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 were resistant to thefour compounds studied (MIC > 128 ,ug ml-´), but Staphylococcus aureus ATCC 25923,ATCC 29213 and 30 clinical isolates of Staph. aureus were inhibited by 2-hydroxy-N-(3,4-dimethyl-5-isoxazoly1)-1,4-naphthoquinone-4-imine (I). This compound diminishedbloodstream infection of mice injected i.m. with Staph. aureus ; septicaemia decayedsignificantly when I was applied at the beginning of the infection while when I was given 3 dafter bacterial challenge, a significant protection was afforded. Bactericidal activity in serumincreased during the 5 h after I was administered i.p.The acetyl derivative of I had a high MIC but when inoculated orally in mice decreasedthe Staph. aureus counts in circulation. This protection occurred only when the schedule ofadministration started close to the bacterial challenge. Antibiotic activity