SOLUBILITY OF BIOACTIVE N-(BENZENESULFONYL)-1,2,3,4-TETRAHYDROQUINOLINE AND N-BENZENESULFONYL-1H-1,2,3-BENZOTRIAZOLE IN WATER/ETHANOL MIXTURES

Congreso; 2° Internacional de Cs. Farm. (RICIFA); 2012

A chemical library of N-benzenesulfonyl derivatives of heterocycles has been prepared and several of them exhibited interesting antiparasitic (1-3) and antibacterial activities. (4) A shortcoming of these compounds is their low aqueous solubility. Therefore, for biological assays and preformulation studies, it is important to know which strategies could be appropriated for enhancing solubility in aqueous media. Two compounds of the aforementioned collection were selected, N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline, BSTHQ, and N-benzenesulfonyl-1H-1,2,3-benzotriazole, BSBZT, for studying their thermodynamic solubility (S) in water/ethanol mixtures. Another objective of this research was to analyze different models that could explain that S behavior and evaluate their capability of prediction.