INVESTIGATION OF THE COCRYSTALLIZATION AND COAMORPHIZATION OF ALBENDAZOLE WITH TRYPTOPHAN.

Congreso; 4°REUNIÓN INTERNACIONAL CS. FARM. (RICIFA 2016),; 2016

Pharmaceutical cocrystallization and coamorphization are relatively recent technologies, which offer an alternative platform to improve the aqueous solubility, dissolution rate and stability of active pharmaceutical ingredients (APIs). Albendazole (ABZ) is an antiparasitic agent that exhibits poor intestinal absorption due to its low aqueous solubility (Sw), thus the improvement of its Sw is a matter of importance. The aim of this study was to prepare coamorphous binary systems or cocrystals of ABZ with tryptophan (TRP), a highly water-soluble coformer