IMPACT OF CRYSTAL HABIT ON IN VITRO BIOPHARMACEUTICAL Performance of Nitazoxanide.

Otro; 3° Internacional de Cs. Farm. (RICIFA; 2014

Poor biopharmaceutical performance of Biopharmaceutical Classification System (BCS) class II active pharmaceutical ingredients (APIs) is a major hurdle in the design and development of pharmaceutical formulations. Polymorphism and the external appearance of crystals (habit) of such APIs can have considerable influence on physicochemical properties and, therefore, on product performance. In the present investigation, a molecule centered approach is presented toward crystal habit modification of nitazoxanide (NTZ), a poorly-water soluble antiparasitic and antiviral API, and its effect on dissolution behavior.