PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF NITAZOXANIDE AND TIXOZANIDE /POLYVINYLPYRROLIDONE K30 FILMS

Otro; 3° Internacional de Cs. Farm. (RICIFA; 2014

The improvement of the solubility and dissolution rate of poorly water-soluble active pharmaceutical ingredients (APIs) represents an important challenge. Such APIs may benefit from formulation approaches that overcome a poor aqueous solubility and/or a dissolution rate-limited bioavailability and, for this purpose, solid dispersions (SD) are frequently proposed.Nitazoxanide (NTZ) and Tixozanide (TIX) are two antiparasitic and antiviral compounds practically insoluble in water, and polyvinylpyrrolidone (PVP) a soluble hydrophilic polymer able to form a SD. The goal of this work was to associate NTX and TIX with PVP K30 in a SD to improve their solubility.