Study of the polymorphism of 1-(4-acetamide-benzenesulfonyl)- benzimidazole a new potential antiprotozoal agent. Part 2: physicochemical properties.

Rosario

Otro; 7ma Reunión Intern Ciencias Farmacéuticas (RICiFa 2023); 2023

1-(4-Acetamido-benzenesulfonyl)-benzimidazole (PABZI), a new benzimidazole derivative with higher inhibitory potency than benznidazole against Trypanosoma cruzi, 1 exhibits crystalline polymorphism. The aim of this study was to determine the equilibrium solubility, powder dissolution rate, wettability and stability towards heat and humidity of the two most viable solid forms of PABZI, viz. the anhydrous form (PABZI-anh) and the isopropanol solvate (PABZI-iso).