Expression of pregnancy specific beta 1-glycoprotein gene in human placenta and hydatiform mole

JL BOCCO; G M PANZETTA DE DUTARI; A FLURY; LC PATRITO

Biochemistry international

International Union of Biochemistry by Academic Press

Lugar: Sydney; Año: 1989 vol. 18 p. 999 - 999

0158-5231

ranscriptional studies of the placental protein Pregnancy Specific beta 1-Glycoprotein (SP1 or PS beta G) gene with a cDNA probe in Northern blot analysis showed 15-20 folds mRNA increase in term placenta compared with early placenta and hydatiform mole. This value parallels the SP1 amount translated in wheat germ cell-free system. We conclude that SP1 biosynthesis is regulated at transcriptional level during placental development and a similar mechanism would occur in hydatiform mole which is a hyperplastic trophoblast tumor.