Release kinetics from LDH-drug hybrids: effect of layers stacking and drug solubility and polarity

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 463 p. 37 - 37

his work highlights the effect of drug solubility and polarity and solid layer stacking on the release rate and mechanism of layered double hydroxides-drug (LDH-D) hybrids. With such a purpose, LDH-D hybrids containing three structural related non-steroidal anti-inflammatory drugs (ibuprofen, naproxen or ketoprofen) were synthesized by a simple co-precipitation method. LDH matrixes exhibited a high drug loading capacity, even exceeding the anion exchange capacity of the solid especially with the more apolar drugs. The structure and interfacial properties of the particulate LDH-D hybrids were also dependent on the polarity of the loaded drug. Finally, the release mechanisms in neutral and acidic media were studied with compressed LDH-D hybrids. The hybrids compression leaded to highly stacked platelets that caused a slower and steadier drug release rate than particulate LDH-D hybrids in all cases. In neutral medium, the drugs were exclusively released by anion exchange with HPO42- ions