Effect of the protein corona on the colloidal stability and reactivity of LDH-based nanocarriers

CARLA E. GIACOMELLI

Journal of Materials Chemistry B

Royal Society of Chemistry

Año: 2016 vol. 4 p. 2008 - 2008

2050-750X

he physicochemical properties of drug nanocarriers such as layered double hydroxides nanoparticles (LDH-NPs) determine their circulation times in biological media and their interaction with the targeted cells. Nevertheless, the components of the biological fluid, and particularly the formation of a protein corona, change the properties of as-prepared nanocarriers. Here, we discuss the effect of the protein corona formation on the colloidal stability and reactivity of LDH-NPs intercalated with chloride (LDH-Cl), carbonate (LDH-CO3) or dodecylsulfate (LDH-DS). These anions represent model physicochemical properties that can be obtained depending on the interaction of the interaction of drugs. The colloidal stability of LDH-NPs was determined in simulated biological fluids at high ionic strengthand/or the presence of albumin (the main protein of human blood plasma), whereas the reactivity was evaluated by dissolution kinetics in acid media, compatible with the environment of cell interna