Interaction Between Eudragit E100 and Anionic Drugs:Addition of Anionic Polyelectrolytes and Their Influence on Drug Release Performance

DANIELA A. QUINTEROS; RUBEN H MANZO; DANIEL A. ALLEMANDI

JOHN WILEY & SONS INC

Año: 2011 vol. 100 p. 1 - 1

BSTRACT: In this work, we report results concerning the study of solid complexes compounded by a cationic polymethacrylate (EudragitR E100, Eu) and mesalazine (M) (Eu–Mx complex). The influence of an anionic polyacrylic acid polymer (carbomer, C) on dissolution behavior of M from the complex was evaluated (Eu–MxCy complex). The dissolution profiles and solvent front movements of solid matrices in different media (water, buffer pH 7.4, 0.9% NaCl) were investigated and ionic interactions among Eu, M, and C were determined through Fourier transform infrared (FT-IR) spectroscopy. For Eu–Mx complexes, the affinity between M and Eu modulated the delivery of free M in solution, with the dissolution media affecting the delivery rate mainly due to an ionic interchange process between M and anionic electrolytes (i.e., Cl−). FTIR spectroscopy allowed the ionic interaction between Eu and M to be verified. The addition of C (Eu–MxCy) influenced the dissolution