Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel

ALICIA FERNANDEZ COLINO; JOSE M. BERMUDEZ; ARIAS VALLEJO JAVIER; DANIELA QUINTEROS; GONZO

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 61 p. 286 - 286

ransversality between mathematical modeling, pharmacology, and materials science is essential inorder to achieve controlled-release systems with advanced properties. In this regard, the area ofbiomaterials provides a platform for the development of depots that are able to achieve controlledrelease of a drug, whereas pharmacology strives to find new therapeutic molecules and mathematicalmodels have a connecting function, providing a rational understanding by modeling the parametersthat influence the release observed. Herein we present a mechanism which, based on reasonableassumptions, explains the experimental data obtained very well. In addition, we have developed asimple and accurate ?lumped? kinetics model to correctly fit the experimentally observed drugreleasebehavior. This lumped model allows us to have simple analytic solutions for the mass andrate of drug release as a function of time without limitations of time or mass of drug released,which represents an important step-forwar