Polyelectrolyte as drug carriers. Analysis by dynamic light scattering of reconstituted and in-situ prepared model polimetacrylate-drug aqueous dispersions.

PALENA, MARÍA CELESTE; ARDUSSO, MARINA; MANZO, RUBÉN HILARIO; JIMENEZ KAIRUZ, ALVARO FEDERICO

The Open Nanoscience Journal

Bentham Science

Año: 2010 vol. 4 p. 1 - 1

1874-1401

bstract: This article reports dynamic light scattering (DLS) data, and electrokinetic -potentials of aqueous dispersions of two linear flexible polymethacrylic acid derivatives Eudragit® L100 (EuL) and S100 (EuS) loaded with two model drugs (D), lidocaine (Ld) and atenolol (At). Dispersions of EuL and EuS at 1,0 % neutralized with increasing percentages (50, 75 and 100 mole %) of each D exhibited a unimodal scattering distribution rendering diffusion coefficients (DC) in the interval of 4 to 9. 10 -9 cm2 /s. All dispersions 50% neutralized exhibited quite similar DC. However, the effect of increasing neutralization followed a different pattern in each Eudragit ®. All dispersions exhibited high negative -potentials that were lower at 100% with respect to 50% loading. Both, DC and -potentials, of redispersed lyophilized samples of (EuL-D) and (EuS-D) remained identical to those of in situ prepared while those of analog samples prepared by solvent evaporation exhibited some sl