Systemic Exposure, Tissue Distribution, and Disease Evolution of a High Solubility Ciprofloxacin?Aluminum Complex in a Murine Model of Septicemia Induced by Salmonella enterica Serotype Enteritidis

BREDA, ANDREA; GUZMAN, MARÍA LAURA; CONFALONIERI, ALEJANDRA; GONZÁLEZ, CLAUDIA; SPARO, MÓNICA; MANZO, RUBEN; SÁNCHEZ BRUNI, SERGIO; OLIVERA, MARIA EUGENIA

MOLECULAR PHARMACEUTICS

AMER CHEMICAL SOC

Lugar: Washington; Año: 2012 vol. 10 p. 598 - 598

1543-8384

new pharmaceutical derivative obtained by stoichiometric complexation of ciprofloxacin (CIP) with aluminum (CIP-complex) has been investigated and reported in this study. Such product has high solubility in the gastrointestinal pH range and was successful in the development of optimized formulations while maintaining its antimicrobial potency. The systemic exposure, tissue distribution, and the disease evolution after given CIP-complex were assessed. The systemic exposure and distribution in intestines, lungs, and kidneys after a single intragastric administration of CIP-complex and CIP given alone, used as reference, were performed in Balb-C mice at a dose of 5 mg CIP/kg. For the assessment of the disease evolution assay, mice were infected with a virulent strain of Salmonella enterica serotype Enteritidis and treated intragastrically once or twice daily during 5 consecutive days with solutions of CIP-complex or the reference. Clinical follow up and survival was measured during 15 d