REDUCED FOOD INTERACTION AND ENHANCED GASTROINTESTINAL TOLERABILITY OF A NEW SYSTEM BASED ON RISEDRONATE COMPLEXED WITH EUDRAGIT E100. MECHANISTIC APPROACHES FROM IN VITRO AND IN VIVO STUDIES

GUZMAN, MARIA LAURA; SORIA, ELIO; LAINO, CARLOS; MANZO, RUBEN; OLIVERA, MARIA EUGENIA

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016

0939-6411

ovel complexes consisting of Eudragit E100-risedronate are presented. The oral bioavailability of risedronate in rats was determined through its percentage excreted in urine after administration of complexed or free risedronate in fed and fasted conditions. The evaluation of the risedronate gastro-duodenal irritation potential was carried out by macroscopic and histological analyses in an experimental rat model. The degree of counterionic condensation between Eudragit E100 and risedronate was assessed by dialysis with, mechanistic information about the interaction with calcium and the release of risedronate from the complexes being obtained using physiological solution and simulated gastric fluid without pepsin. Non-significant differences were observed in the urinary excretion of risedronate when the complex or free risedronate was administered to fasted rats. However, the urinary excretion of risedronate in the complex group was 4-times higher than in the free risedronate group when