Liposomes can both enhance or reduce drugs penetration through the skin

GUZMAN, ML; PERALTA, MARÍA FLORENCIA; PÉREZ AP; APEZTEGUIA GA; FORMICA ML; ROMERO EL; MARIA E OLIVERA ME; CARRER, DOLORES

Scientific Reports

natureresearch

Año: 2018

he adequate formulation of topical vehicles to treat skin diseases is particularly complex. A24 desirable formulation should enhance the accumulation of the active drugs in the target tissue25 (the skin), while avoiding the penetration enhancement to be so large that the drugs reach the26 systemic circulation in toxic amounts. We have evaluated the transcutaneous penetration of27 three drugs chosen for their widely variable physicochemical properties: Amphotericin B,28 Imiquimod and Indole. We incorporated the drugs in fluid or ultra-flexible liposomes. Ultra29flexible liposomes produced enhancement of drug penetration into/through human skin in all30 cases in comparison with fluid liposomes without detergent, regardless of drug molecular31 weight. At the same time, our results indicate that liposomes can impede the transcutaneous32 penetration of molecules, in particular small ones.