DRUG DELIVERY SYSTEMS BASED ON POLYELECTROLYTE-DRUG-FATTY ACIDS TERNARY COMPLEXES FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS

GUZMAN, MARIA LAURA; ARRIGONI, KAREN; CARRER, DOLORES; MARIA E OLIVERA ME

Mar del Plata

Congreso; Reunión anual de Sociedades Biocientíficas en la que participarán 2019 (SAFE entre otras); 2019

Cutaneous Leishmaniasis is the most prevalent form of Leishmaniasis in South America. A topical treatment is attractive because of its potential to reduce side effects, increase patient compliance and its affordability. Biphosphonates and Eudragit E (EE) have shown to be active against some forms of Leishmania. Previous studies showed that Ris complexing with EE give raised to a new material EuE-Ris with appropriate properties for topical administration. Besides it showed in vivo anti-Leishmania activity. The literature also describes the antileishmania activity for medium chain fatty acids.Our hypothesis is that the development of systems based on materials with antileismania properties: EE-Ris-Capric Acid (CA), would contribute to topical therapy to treat cutaneous leishmaniasis. The specific objectives of this work were: a) to obtain and physicochemically characterize homologous series of EE-Ris-CA systems; b) to evaluate the ability of EE-Ris-CA systems to load other drugs with antileishmania activity. c) to evaluate the release properties of the loaded drugs.All systems evaluated resulted in translucent, homogeneous and physically stable mixtures, which was considered an indicative aspect of the formation of a salt or complex between the fatty acid and the components of the EE-Ris complex. When the percentage of CA exceeds 120%, Z potential was considerably increased. On the other hand, there was also an increase in the proportion of 200nm particles (PDI>0.3). These results, could be attributed to a greater exposure of the basic groups of EE, due to changes in the conformation. Besides, pHs value were compatible with topical route (pH:5-6). Interestingly, a second drug with antileishmania activity was added. When Ris kinetic release from EE-Ris-CA was evaluated, an additional increase in the release of Ris was founded in all media tested with regard to EE-Ris, that would indicate a Ris release more sensitive to the presence of electrolytes. This behaviour is maintained after the addition of the second antileishmania drug. A new material containing antileishmanial drugs and excipients was obtained which would contribute to topical therapy to treat cutaneous leishmaniasis.