LOW OXYGEN TENSION INDUCES KRÜPPEL LIKE FACTOR 6 EXPRESSION IN TROPHOBLAST CELLS

RACCA, ANA C.; RIDANO, MAGALÍ EVELIN; BANDEIRA, CARLA L; BEVILACQUA, ESTELA; AVVAD PORTARI, ELYZABETH; GENTI-RAIMONDI, SUSANA; GRAHAM, CHARLES H.; PANZETTA-DUTARI, GRACIELA

PLACENTA

W B SAUNDERS CO LTD

Lugar: Londres; Año: 2016 vol. 45 p. 50 - 50

0143-4004

he transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the involvement of oxygen in the regulation of KLF6 expression remains unexplored. In the present study we examined the expression of KLF6 in placental tissue from uncomplicated and preeclamptic pregnancies, the latter often characterized by an inadequately perfused placenta. We also determined the effect of hypoxia and the involvement of the Hypoxia Inducible Factor 1α (HIF-α) on the expression of KLF6 in cultured trophoblast cells and placental tissues. Results revealed that villous, interstitial and endovascular extravillous cytotrophoblasts from placentas from normal and preeclamptic pregnancies express KLF6. In addition, KLF6 immunoreactivity was higher in the place