Mathematical and Pharmacokinetic Approaches for the Design of New 3D Printing Inks Using Ricobendazole

BARBERIS, EUGENIA; PALMA SD; ELIO EMILIO GONZO; BERMÚDEZ, J.M.; MARIANELA LORIER; MANUEL IBARRA; J.P. REAL

PHARMACEUTICAL RESEARCH

SPRINGER/PLENUM PUBLISHERS

Lugar: New York; Año: 2022

0724-8741

urpose: 3D printing (3DP) makes it possible to obtain systems that are not achievable with current conventional methods, one of them, sustained release floating systems. Floating systems using ricobendazole (RBZ) as a model drug and a combination of polymers were designed and obtained by melt solidification printing technique (MESO-PP).Methods: Four different MESO-PP inks were formulated based on combinations of the polymers Gelucire 43/01 and Gelucire 50/13 in different ratios. For each of the formulated inks, physicochemical characterization was performed by thermal analysis (thermogravimetric analysis [TGA] and differential scanning calorimetry [DSC]), fourier transform infrared spectrophotometer (FTIR) and X-ray diffraction (XRD). Pharmaceutical characterization was performed by in vitro assays to determine pharmaceutically relevant parameters. These parameters were calculated by applying mathematical models developed to evaluate in vitro drug release profiles. On the other hand,