Design, formulation and characterization of lipid inks containing ricobendazole applying a 3D printing technique by fusion solidification (MESO-PP) adjusted to a mathematical model to describe the release of the drug

BARBERIS, EUGENIA; REAL J.P; BERMÚDEZ, J.M.; PALMA SD

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1); 2021

3D printing (I3D) allows obtaining systems that are not achievable with current conventional methods, one of them, sustained release gastro-retentive systems. The aim of this work was to design, through I3D MESO-PP (Melting solidification printing process), a series of gastro-retentive systems using ricobendazole (RBZ) as a model drug and Gelucire (G) as carrier polymers. Solid oblong (IS) prints were designed and formulated with 4 different inks, all 25% loaded with RBZ, using a combination of G50-13 and G43-01. The proportions of G50-13: G43-01 of Inks 1, 2, 3, and 4 was 4:1, 2:1, 1:1, 1:2 respectively. Dissolution studies demonstrated the influence of ink on the buoyancy and kinetics of RBZ release process. Inks 1, 2, 3, and 4 presenteda float time of 102 ± 14 min; 182 ± 30 min; 240 ± 25 min and 475 ± 25 min (molded inks, without the air gap that printing produces, did not have the ability to float on their own) , t80%56.2, 74.1, 157.7 and 473 min and a release rate (RR) at 10 and 60 min about 0.528-2.973, 0.467-1.569, 0.363-0.503, and 0.201-0.180 %/min, respectively. The XRD, FTIR, HSM, and SEM studies showed that RBZ, in all inks, remained suspended and homogeneously distributed without physicochemical changes. It can be concluded that MESO-PP allowed to obtain floating IS with different release profiles as a function of the G proportions.