Antiproliferative and Quinone Reductase Inducing activities of Withanolides derivatives

GARCÍA, M.E.; NICOTRA, V.E.; OBERTI, J.C.; RIOS-LUCI, L.; MARLER, L.; LI, G.; PEZZUTO, J.M.; VAN BREEMER, R.B.; PADRÓN, J.M., ; HUESO-FALCÓN, I.; ESTÉVEZ BRAUN A.

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Lugar: Paris; Año: 2014 vol. 82 p. 68 - 68

font size="1" face="AdvOT863180fb"> Two new and five known withanolides (jaborosalactones 2, 3, 4, 5, and 24) were isolated from the leaves of Jaborosa runcinata Lam. We also obtained some derivatives from jaborosalactone 5, which resulted to be the major isolated metabolite. The natural compounds as well as derivatives were evaluated for their antiproliferative activity and the induction of quinone reductase 1 (QR1; NQ01) activity. Structureeactivity relationships revealed valuable information on the pharmacophore of withanolide-type compounds. Three compounds of this series showed significant