Antiproliferative activity of withanolide derivatives from Jaborosa cabrerae and J. reflexa

GARCÍA, M.E.; BARBOZA, G.E.; OBERTI, J.C.; RIOS, L.; PADRÓN, J.M.; NICOTRA, V.E.; ESTEVEZ-BRAUN, A.; GUTIERREZ RAVELO, A.

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Oxford; Año: 2012

font face="Times New Roman"> Three new withanolides were isolated from the aerial parts of Jaborosa reflexaJaborosa reflexa Phil. Jaborosa cabrerae Barboza yielded five sativolide withanolides (including 5 jaborosalactones R, S, 38, and 39) and two trechonolide withanolides epimeric at C-23 (trechonolide A and jaborosalactone 32). In addition, five new derivatives were obtained by chemical derivatization of jaborosalactone 38. All new compounds were fully characterized by 1D and 2D NMR spectroscopic studies. The in vitro antiproliferative activities of the major natural withanolides and the semisynthetic derivative