Withanolides from Three Species of the Genus Deprea (Solanaceae). Chemotaxonomical considerations

CASERO C.N.; OBERTI, J.C.; CLARA INÉS OROZCO; ALEJANDRO CÁRDENAS; IVÁN BRITO; GLORIA BARBOZA; NICOTRA VIVIANA

JOURNAL OF NATURAL PRODUCTS

AMER CHEMICAL SOC

Lugar: Washington; Año: 2015 vol. 103 p. 83 - 83

0163-3864

ine withanolides were isolated from the aerial parts of Deprea bitteriana, Deprea cuyacensis, and Depreazamorae. D. bitteriana yielded two withaphysalins, D. cuyacensis gave two 13,14-seco withaphysalins,while D. zamorae yielded five physangulidines. The compounds were fully characterized by a combinationof spectroscopic methods (1D and 2D NMR and MS). All compounds isolated from D. bitterianaand D. cuyacensis were obtained as epimeric mixtures at C-18. The structure of physangulidine D wasconfirmed by X-ray diffraction analysis. The skeletons found in this research support the chemotaxonomicalposition of the genus Deprea in the tribe Physalideae.