Novel terpenoids from Plenckia integerrima and biotechnology of Maytenus canariensis
F. Gutiérrez-Nicolás1,2, A. Estévez-Braun 1,2, R. Zárate 1,2, J. C. Oberti3 and A. G. Ravelo 1,2.
1 Instituto Universitario de Bio-Orgánica ?Antonio González?, Universidad de La Laguna, Av. Francisco Sánchez 2, 38206 La Laguna,Tenerife, Spain.
2Instituto Canario de Investigación del Cáncer (ICIC) La Laguna,Tenerife, Spain.
3 Facultad de Ciencias Químicas, Universidad de Córdoba. Av. Haya de la Torre s/n, Córdoba, Argentina.
As part of our ongoing research program to isolate bioactive compounds focused on antitumoral products belonging to the Celastraceae family used in South America1, Plenckia integerrima (Lundell), was studied. This species is used as antidysenteric and anti-rheumatic agent in popular medicine.2 The EtOH extract of the root bark of P. integerrima was repeatedly chromatographed to yield seven new terpenoids, five of them agarofuran sesquiterpenes and two known products (evonomine and rhamnose). Their structures were determined by means of 1H and 13C NMR spectroscopy studies, including 1H-13C heteronuclear correlation, (COSY, ROESY, HSQC and HMBC). All new compounds were tested on different biological assays.
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