Fe3O4@Au@mSiO2 as Enhancing Nano-platform for Rose Bengal Photodynamic Activity

ROSA PARDO, IGNACIO; ROIG-PONS, MARTA; HEREDIA, ADRIAN A; USAGRE, JOSE VICENTE; RIBERA, ANTONIO; GALIAN, RAQUEL E. EUGENIA; PEREZ-PRIETO, JULIA

Nanoscale

Royal Society of Chemistry

Lugar: Cambridge; Año: 2017 vol. 9 p. 10388 - 10388

2040-3364

novel nanoplatform composed of three types of materials with different functionalities, specifically core-shell Fe3O4@Au nanoparticles encapsulated near the outer surface of mesoporous silica (mSiO2) nanoparticles, has been successfully synthesised and used to enhance the efficiency of a photosensitiser, namely Rose Bengal, in singlet oxygen generation. The Fe3O4 is responsible for the unusual location of the Fe3O4@Au nanoparticle, while the plasmonic shell acts as an optical antenna. In addition, the mesoporous silica matrix firmly encapsulates Rose Bengal by chemical bonding inside the pores, thus guaranteeing its photostability, and it makes the nanosystem biocompatible. Moreover, the silica surface of the nanoplatform ensures further functionalisation on demand.