LSP1 DEFICIENT MICE HAVE AN IMPAIRED CYTOTOXIC RESPONSE AFTER ANTIGEN EXPOSURE

ACLAND STRACK, RACHEL PAOLA; ZACCA, ESTEFANIA; PASCUAL, MARÍA MERCEDES; PISTORESI, MARÍA CRISTINA

Buenos Aires

Congreso; LXIII SAI; 2015

Background: The leukocyte-specific protein 1 (LSP1), is a 52-kDa cytoplasmic F-actin binding phosphoprotein expressed in all human and murine leukocytes as well as in endothelial cells. LSP1 is an important regulator of actin cytoskeleton remodeling, modulating neutrophil motility. No information is available about the role of LSP1 in the triggering of immune response, particularly in the biology of antigen presenting cells. We have previously reported that dendritic cells from Lsp1-/- mice fail to induce a strong CTL response upon transfer to wild-type mice. CONCLUSION: Lsp1-/- mice have a lower capacity to generate OVA-specific CD8+T cells and consequently an impaired cytotoxic response. This could be related to an abnormal antigen presentation by DCs as we have previously reported. The higher tumor growth rate in Lsp1-/- mice could be considered a consequence of this impaired immune response.