Mecanismos de acción de hormonas tiroideas. Aspectos Moleculares y Genéticos. (REVISIÓN POR INVITACIÓN)

PELLIZAS CG, MONTESINOS MM, MASINI-REPISO AM, COLEONI AH

REVISTA ARGENTINA DE ENDOCRINOLOGIA Y METABOLISMO

Gráfica Latina S.A.

Lugar: Buenos Aires, Argentina; Año: 2002 vol. 39 p. 220 - 220

0080-2077

dir> Thyroid hormones (TH) are essential for normal development, differentiation and metabolic balance. Their actions are mediated by multiple thyroid hormone receptor (RT3) isoforms, expressed by two different genes. RT3 are members of a superfamily of nuclear hormone receptors that also include receptors for other small lipophilic hormones. The RT3 structure is arranged in several domains, each of them with specific functions. Frecuently, RT3 are in the form of heterodimer with the 9 cis-retinoid acid receptor. RT3 controls the transcription of different target genes by the recruitment of protein complexes that modify the chromatin components. In the absense of the ligand, the transcriptional activity is repressed due to the formation of a corepressor complex between RT3 and several proteins with histone deacetilase activity. The binding of the ligand T3 to the RT3 changes the conformation of the RT3 in such a way