Thyroid iodide transport is reduced by administration of monoamine oxidase A inhibitors to rats

CABANILLAS ANA M, MASINI-REPISO ANA M, COSTAMAGNA MARÍA E, PELLIZAS CLAUDIA, COLEONI ALDO H.

JOURNAL OF ENDOCRINOLOGY

The Dorset Press, Dorchester

Lugar: Dorset, Great Britain; Año: 1994 vol. 143 p. 303 - 303

0022-0795

dir> The present work was addressed to study a possible relationship between monoamine oxidase (MAO) and the thyroid iodide transport mechanism. Normal rats treated with clorgyline (a selective MAO-A inhibitor) or tranylcypromine (a non-selective MAO inhibitor) showed a significantly diminished thyroid MAO activity, while deprenyl and pargyline (MAO-B inhibitors) did not modify the thyroidal enzyme activity with respect to the control group. Under these conditions, in vivo iodide transport was reduced both by clorgyline and tranylcypromine administration whereas it remained unchanged after treatment with MAO-B inhibitors. The effect of MAO inhibitors on thyroid MAO activity and in vivo iodide transport was also evaluated in rats treated with exogenous thyrotrophin (TSH) after endogenous TSH secretion blockade produced by T4 administration. In this condition, thyroid MAO activity was significantly lowered by clorgyline and was not modified b