Thyroid hormone receptor B1 gene expression is increased by Dexamethasone at transcriptional level in rat liver

M.M. MONTESINOS *, C.G. PELLIZAS, M.L. VELEZ, S. SUSPERREGUY, A.M. MASINI-REPISO, A.H. COLEONI

LIFE SCIENCES

Elsevier Inc.

Lugar: Saint Louis, USA.; Año: 2006 vol. 78 p. 2584 - 2584

0024-3205

font color="#231f20" face="AdvTT5843c571" size="1"> Triiodothyronine (T3) exerts most of its effect through nuclear thyroid hormone receptors (TR) which bind mainly as heterodimers with retinoid-X receptors (RXR) to thyroid hormone response elements (TRE) in target genes. It is well known that the synergistic interaction of T3 and glucocorticoids has a role on the synthesis of growth hormone in rat pituitary cell lines and in the T3-induced metamorphosis in amphibians. Glucocorticoids increased mRNAs of T3-regul