Control of dendritic cell maturation and function by triiodothyronine

MASCANFRONI I; MONTESINOS MM; SUSPERREGUY S; CERVI L; ILARREGUI JM; RAMSEYER V; MASINI - REPISO AM; TARGOVNIK HÉCTOR M; RABINOVICH GABRIEL A; PELLIZAS CLAUDIA G

FEDERATION AMER SOC EXP BIOL

Lugar: Nueva York; Año: 2008 vol. 22 p. 1032 - 1032

b> Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence of thyroid hormone receptors (TRs) and the impact of THs in the physiology of mouse dendritic cells (DCs), specialized antigen-presenting cells with the unique capacity to fully activate naive T cells and orchestrate adaptive immunity. Both immature and lipopolysaccharide-matured bone marrow-derived DCs expressed TRs at mRNA and protein levels, showing a preferential cytoplasmic localization. Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatibility complex II, CD80, CD86, and CD40), markedly increased the secretion of interl