MASINI ANA MARIA DE LAS MERCEDES
Artículos
Título:
Emerging Therapeutics for Radioiodide-Refractory Thyroid Cancer
Autor/es:
NICOLA JUAN PABLO; MASINI - REPISO ANA MARIA
Revista:
Journal of Analytical Oncology
Editorial:
LIFESCIENCE GLOBAL
Referencias:
Lugar: Viena; Año: 2016 vol. 5 p. 75 - 75
Resumen:
lthough uncommon, thyroid cancer constitutes the main endocrine neoplasia with an incidence rate that has been increasing steadily over the past decades. Recently, remarkable advances have occurred in understanding the biology of thyroid cancer. Novel germline and somatic point mutations as well as somatic chromosomal rearrangements associated with thyroid carcinogenesis have been discovered. Strikingly, acquired knowledge in the genetics of thyroid cancer has been translated into clinical practice, offering better diagnostic and prognostic accuracy and enabling the development of novel compounds for the treatment of advanced thyroid carcinomas.Even after 70 years, radioiodide therapy remains as the central treatment for advanced or metastatic differentiated thyroid cancer. However, the mechanisms leading to reduced radioiodide accumulation in the tumor cell remain partiallyunderstood. Radioiodide-refractory thyroid cancer metastasis constitutes a central problem in the management of