GENTI DE RAIMONDI SUSANA DEL VALLE
Artículos
Título:
Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells
Autor/es:
CAMOLOTTO SOLEDAD; RACCA ANA; RENA VIVIANA; NORES RODRIGO; PATRITO LUIS; GENTI DE RAIMONDI SUSANA; PANZETTA-DUTARI GRACIELA
Referencias:
Lugar: Londres; Año: 2010 vol. 31 p. 312 - 312
Resumen:
uman pregnancy-specific glycoproteins (PSGs), encoded by eleven highly conserved genes, are the
major placental polypeptides. Low PSG levels in maternal circulation have been associated with
complicated pregnancies. However, expression of each PSG gene and their regulation during cytotrophoblast
cell differentiation remain poorly explored. Herein, we analyze the expression of five PSG
genes and demonstrate that they are almost undetectable in undifferentiated trophoblast, but are all
transcribed in differentiated cells. Among them, PSG1, PSG3 and PSG5 genes achieve high mRNA levels
while PSG7 and PSG9 are poorly expressed. In addition, total PSG proteins and transcripts markedly
increase during trophoblast differentiation, preceding morphological syncytialization and bhCG
expression. The 50 regulatory region contributes to the transcriptional control of PSG gene induction in
trophoblast cells undergoing differentiation. This responsive region in PSG3 maps within a 130 bp
pro