Low oxygen tension induces Krüppel-Like Factor 6 expression in trophoblast cells

RACCA ANA; RIDANO; BANDEIRA C; BEVILACQUA ESTELA; AVVAD-PORTARI E; GENTI DE RAIMONDI SUSANA; GRAHAM CH; PANZETTA DE DUTARI GRACIELA

PLACENTA

W B SAUNDERS CO LTD

Lugar: Londres; Año: 2016 vol. 45 p. 50 - 50

0143-4004

he transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis,apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for properplacental development. While oxygen is a critical mediator of trophoblast differentiation and function,the involvement of oxygen in the regulation of KLF6 expression remains unexplored. In the present studywe examined the expression of KLF6 in placental tissue from uncomplicated and preeclamptic pregnancies,the latter often characterized by an inadequately perfused placenta. We also determined theeffect of hypoxia and the involvement of Hypoxia-Inducible Factor 1a (HIF-1a) on the expression of KLF6in cultured trophoblast cells and placental tissues. Results revealed that villous, interstitial and endovascularextravillous cytotrophoblasts from placentas from normal and preeclamptic pregnancies expressKLF6. In addition, KLF6 immunoreactivity was higher in the placental bed of preeclampt