GENTI DE RAIMONDI SUSANA DEL VALLE
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Título:
SuppressionofStarD7promotesendoplasmicreticulumstressand induces ROSproduction
Autor/es:
FLORES-MARTÍN JÉSICA; REYNA LUCIANA; RIDANO MAGALI; GENTI DE RAIMONDI SUSANA
Revista:
FREE RADICAL BIOLOGY AND MEDICINE
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 99 p. 286 - 286
ISSN:
0891-5849
Resumen:
tarD7isanintracellularlipidtransportproteinidentified asup-regulatedinthechoriocarcinomaJEG-3cell line.StarD7facilitatesthedeliveryofphosphatidylcholine(PC)tothemitochondria,andStarD7knockdowncausesareductioninphospholipidsynthesis.SinceinhibitionofPCsynthesismayleadtoendoplasmic reticulum(ER)stresswehypothesizedthatStarD7maybeinvolvedinmaintainingcellhomeostasis. Here,weexaminedtheeffectofStarD7silencingonERstressresponseandonthelevelsofreactiveoxygenspecies(ROS)inthehumanhepatomacelllineHepG2.StarD7knockdowninducedal-terationsinmitochondriaandERmorphology.ThesechangeswereaccompaniedwithanERstressre-sponse asdeterminedbyincreasedexpressionofinositol-requiringenzyme1α (IRE1α), calnexin,glucoseregulatedprotein78/immunoglobulinheavychain-bindingprotein(Grp78/BiP),proteinkinase-likeERkinase (PERK)aswellasthephosphorylatedeukaryotictranslationinitiationfactor2,subunit1α (peIF2α).Additionally,adownregulationofthetumorsuppressorp53byadegradationmechanismwasobserved inSta
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