Resumen:
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It has been demonstrated that c-Fos has, in addition to its well
recognized AP-1 transcription factor activity, the capacity to
associate to the endoplasmic reticulum and activate key
enzymes involved in the synthesis of phospholipids required for
membrane biogenesis during cell growth and neurite formation.
Because membrane genesis requires the coordinated supply of
all its integral membrane components, the question emerges as
to whether c-Fos also activates the synthesis of glycolipids,
another ubiquitous membrane component. We show that c-Fos
activates the metabolic labeling of glycolipids in differentiating
PC12 cells. Specifically, c-Fos activates the enzyme glucosylcerami