Controlling cytoplasmic c-Fos controls tumor growth in the peripheral and the central nervous system.

GA GIL; DC SILVESTRE; N TOMASINI; DF BUSSOLINO; BL CAPUTTO.

SPRINGER/PLENUM PUBLISHERS

Lugar: New York; Año: 2012 vol. 37 p. 1364 - 1364

font face="Arial"> Some 20 years ago c-Fos was identified as a member of the AP-1 family of inducible transcription factors (1). More recently, an additional activity was described for this protein: it associates to the endoplasmic reticulum and activates the biosynthesis of phospholipids (2,3), the quantitatively most important component of cellular membranes. This latter activity of c-Fos determines the rate of membrane genesis and consequently of growth in differentiating PC12 cells (3). In addition, it has been shown that c-Fos is over-expressed both in PNS and CNS tumors (4). Herein, it is shown that c-Fos-activated phospholipid synthesis is required to support membrane genesis during the exacerbated growth characteristic of brain tumor cells. Specifically b