Artículos
Título:
c-Fos is surface active and interacts differentially with phospholipid monolayers
Autor/es:
GA BORIOLI; BEATRIZ L CAPUTTO; B MAGGIO
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2001 vol. 280 p. 9 - 9
Resumen:
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The transcription factor c-Fos forms stable Gibbs
and Langmuir monolayers at the air-buffer interface.
Its marked surface activity is enhanced by penetration
into phospholipid films above the protein’s own
maximum adsorption surface pressure to a lipid-free
interface. The protein-phospholipid stabilizing interactions
at the interface depend on the lipid polar head
group and the increases of lateral surface pressure
generated are comparable to those of membraneactive
proteins. The surface activity of c-Fos is strong
enough to thermodynamically drive and retain c-Fos
at the membrane interface where it may exert direct
or indirect effects.