Posttranslational arginylation of brain proteins

M. E. HALLAK Y G. BONGIOVANNI

NEUROCHEMICAL RESEARCH

Año: 1997 p. 467 - 467

0364-3190

p class="MsoNormal" style="MARGIN: 0cm -0.05pt 0pt 0cm; LINE-HEIGHT: 24pt; TEXT-ALIGN: justify">The knowledge of brain protein metabolism is important in understanding nervous system brain function. Protein synthesis rates are high in young brain, decline rapidly at adult stages, and thereafter continue falling slowly with age. The breakdown of protein appears to follow a similar rate (1). Protein synthesis and degradation however, are only the two extremes of a complex phenomena which includes a variety of other protein modifications.             Proteolytic cleavage is the most common covalent modification of