Interaction between alpha-MSH and acetylcholinergic system upon striatal cAMP and IP(3) levels

MC CREMER,; RUBIALES DE BARIOGLIO, SUSANA ELIZABETH; ME CELIS,

ELSEVIER SCIENCE INC

Año: 2000 vol. 21 p. 669 - 669

he interaction between the neuropeptide α-MSH and the acetylcholinergic system as reflected by changes in cAMP and inositol 1?3-5 triphosphate(IP3)production was investigated in an in vitro model of striatal slices. The possible involvement of D1 receptors in cholinergic and α-MSH- stimulated cAMP and IP3 production in slices of rat striatum was also examined, because it has been demonstrated that acetylcholinergic drugs induce endogenous dopamine release in the striatum. α-MSH, pilocarpine(PL) and the selective muscarinic M1 agonist McN-A-343 increased cAMP and IP3 striatal levels, effects blocked by the D1 antagonist SCH-23390, except for the effects of α-MSH on IP3 .The muscarinic M2 antagonist gallamine (GL) brought about an increase in cAMP levels, an effect blocked by SCH-23390. The M1 antagonist pirenzepine (Pz) induced a decrease both in cAMP and IP3 content, and the nicotinic antagonist di-hydro-β-eritroidine(DBE) only diminished cAMP production. When