In vitro activity of N-Benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms

M.C. BECERRA; N. GUIÑAZÚ; LY HERGERT; A. PELLEGRINI ; M. R. MAZZIERI ; S. GEA; I. ALBESA

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2012

p style="LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">Chagas disease is still an important health problem in Central and South America. However, the only drugs currently available for specific treatment of this disease can induce toxic side effects in the host. The aim of this work was to determine the activity of N-benzenesulfonylbenzotriazole (BSBZT) against the protozoan parasite Trypanosoma cruzi. The effects of BSBZT, benzotriazole (BZT) were compared to Benznidazole (BZL) on epimastigote and trypomastigotes forms. BSBZT was found to have an in vitro growth inhibitory dose-dependent activity against epimastigotes. In addition, flow cytometry analysis confirmed that the treated parasites presented size reduction. BSBZT showed an IC50 of 21.56