Preparation and characterization of a new alternative formulation of sodium p-aminosalicylate

L.Y. HERGERT; D.A ALLEMANDI; N.R.SPERANDEO; M.R. MAZZIERI

INTERNATIONAL JOURNAL OF PHARMACEUTICAL COMPOUNDING

Año: 2011 vol. 15 p. 344 - 344

odium p-aminosalycilate is an orphan drug used in patients affected with Multidrug-resistant Tuberculosis. In this article, the preparation and characterization of a new alternative formulation of p-aminosalycilate is described. It consists of a powder for extemporaneous reconstitution,p-aminosalycilate?extemporaneous, to be orally administrated in solution. It is finally packaged in a tightly closed, light-resistant glass container as a unitary dose. In order to promote accessibility to Multidrug-resistant Tuberculosis treatment, the formulation is low cost and simple tomanufacture, being compounded by only four ingredients. To improve patient compliance and treatment adherence, the unpleasant taste of p-aminosalycilate was masked as p-aminosalycilate?extemporaneous is easy to drink. The p-aminosalycilate?extemporaneous was characterized inrelation to its content uniformity, time of blending, powder bulk properties (flowability), and stability. The proposed alternat