Mode of action of sulfanilyl fluoroquinolones (NSFQs).

F. ALOVERO; M. NIETO; M. MAZZIERI; R. THEN; R. H. MANZO

AMER SOC MICROBIOLOGY

Año: 1998 vol. 42 p. 1495 - 1495

font size="1" face="Dutch801BT-Bold"> The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions with p-aminobenzoic acid and trimethoprim suggested that a sulfonamide like mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed DNA supercoiling that is similar to the activity of other fluoroquinolones. Also, NSFQ-105 uptake was decreased by the presence of Mg2