Preparation and characterization of new solid forms of Tizoxanide

Otro; IV Reunión Internacional de Ciencias Farmacéuticas (RICiFa); 2016

IntroductionTizoxanide (TIZ), an antimicrobial family of thiazolides crystallizes in a crystal lattice graphitic type, which is unusual in possessing drugs and determines solid state high stability and very low aqueous solubility (Sw). The objective of this study was to prepare and characterize solid dispersions (SD) and cocrystals forms of TIX to determine whether crystallization It can be inhibited by polymeric supports or other drugs and thus improve Sw.Materials and MethodsThis work studied the interaction between anti-infective agent Tizoxanide (TZ) with albendazole (AL), chitosan low (ChL) and chitosan higth (ChH). Solid dispersions of TZ and polymers were prepared by coevaporation of their ethanol solutions. Cocrystals of TZ and AL were prepared by liquid asitid grinding using acetonitrile. The resulting coevaporates were characterized in the solid state by Hot Stage Microscopy (HSM), Powder X-ray Diffraction (PXRD) and Fourier Transform Infrared (FTIR).Results and discussionThe SD TZ-ChL and TZ-ChH were prepared by coevaporation, According to HSM the samples showed melting point (mp) similar to TZ, within to the experimental error of the Kofler method. The FTIR spectra of the samples not showed changes in the characteristic absorption bands of TZ, ChL and ChH. PDRX of the samples was observed the changes in the disappearance of characteristic reflection planes of TZ.TZ-AL cocrystal were prepared by liquid asitid grinding. According to HSM the sample was observed change in the mp according to TZ and AL. The FTIR spectra of the sample showed changes in the characteristic absorption bands of TZ and AL. PDRX of the samples not showed changes in the disappearance of characteristic reflection planes of TZ.ConclusionsThe SD TZ-ChL and TZ-ChH not showed changes in the FTIR spectral and in the mp but in the DRXP was observed disminution of the cristalinity.The sample TZ-AL showed changes in the FTIR spectral and in the mp indicating a possible interactions between these drugs.