Autor/es:
MORÓN, G; MALETTO, B; ORSILLES, M; DEPIANTE, M; PISTORESI, MC
Resumen:
xperimental autoimmune prostatitis (EAP) is an experimental model of autoimmune
disease, developed in Wistar rats against prostatic components. The 12-and 18-month-old
rats with EAP show a higher cellular autoimmune response and lower humoral autoimmune
response compared to 3-month-old rats. The analysis of NO· and O2
production by
peritoneal exudate cells (PECs) resulted in a higher NO· and O2
production in EAP rats at
all ages, compared to control animals. PECs from 12- and 18-month-old rats produced more
NO· and less O2
than PECs from 3-month-old rats. However, lipopolysacharide (LPS) did
not stimulate PECs from aged rats for NO· production as much as in 3-month-old rats and
thus, turning out in a lower index of LPS-stimulation of PECs from aged rats, compared to
3-month-old rats. Furthermore, the mast cells number in prostates of EAP rats, especially
the number of degranulated cells, was higher than in control animals, but no significant
differences were found bet