B cell from aged mice exhibit reduced apoptosis upon BCR stimulation and differential ability to up-regulate survival signals.

MONTES C; MALETTO B; ACOSTA RODRIGUEZ E; GRUPPI A; PISTORESI-PALENCIA MC

CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Año: 2006 vol. 143 p. 30 - 30

0009-9104

b> During ageing, autoimmune disorders and the higher susceptibility to infectious have been associated with alterations in the humoral immune response. We report that splenic B lymphocytes from aged mice exhibit lower level of apoptosis induced by B-cell antigen receptor (BCR) ligation in vitro . Respect to B cells from young mice the anti-ìì stimulated aged B cells show similar Bcl- 2 and Bcl-xL expression but differential kinetic of A1 degradation and a higher level of cFLIP and FAIM. Even though B cells from aged mice