Association between levels of synovial anti-citrullinated peptide antibodies and neutrophil response in patients with rheumatoid arthritis

GORLINO, C; DAVE, M; BLAS, R; CRESPO, MI; LAVANCHY, A; TAMASHIRO, H; PARDO HIDALGO, RA; PISTORESI, MC; DI GENARO, S

EUROPEAN JOURNAL OF IMMUNOLOGY

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2018 vol. 48 p. 1563 - 1563

0014-2980

heumatoid arthritis (RA) is characterized by the presence of anti-citrullinated peptide antibodies (ACPAs) and neutrophils infiltrating the synovial fluid (SF) of the affected joints. The aim of this work was to analyze whether the presence of ACPAs is associated with neutrophil infiltration and with their phenotype in the inflamed joints of RA patients. We found that in the presence of ACPAs, the number of synovial neutrophils correlated with severe disease activity. The SF were divided according to ACPA levels in negative-(