Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area

RIVAROLA HW, BUSTAMANTE JM, LO PRESTI S, FERNANDEZ AR, ENDERS JE, GEA S, FRETES R, PAGLINI-OLIVA P

EXPERIMENTAL PARASITOLOGY

Año: 2005 vol. 111 p. 80 - 80

0014-4894

nbsp;The susceptibility of Trypanosoma cruzi strains to nifurtimox and benznidazole has been investigated and resistant strains havebeen described.Some tricyclic drugs are lethal for trypomastigote and epimastigote forms of T.cruzi (Tulahuen strain)and prevent the disease in mice. We investigated whether clomipramine, a tricyclic antidepressant drug with anti-trypanothione reductase and anti-calmodulin effects, could be effective in treating Albino Swiss mice infected with trypomastigotes of a new T.cruzi isolate from a chronic patient from an endemic area of Argentina in two different treatment schedules. Both treatment schedules were effective in reducing electrocardiographic changes and preventing myocardial structural damage. The cardiac