Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection.

CARRERA-SILVA EA, GUIÑAZU N, PELLEGRINI A, CANO RC, AROCENA A, AOKI MP, GEA S.

PUBLIC LIBRARY SCIENCE

Año: 2010 vol. 4 p. 863 - 863

font size="2" face="AdvP40319B"> Background: Toll-like receptors (TLR) and cytokines play a central role in the pathogen clearance as well as in pathological processes. Recently, we reported that TLR2, TLR4 and TLR9 are differentially modulated in injured livers from BALB/c and C57BL/6 (B6) mice during Trypanosoma cruzi infection. However, the molecular and cellular mechanisms involved in local immune response remain unclear. Methodology/Principal Findings: In this study, we demonstrate that hepatic leukocytes from infected B6 mice produced higher amounts o