Heat killed cells of Cryptococcus neoformans var. grubii induces protective immunity in rats: immunological and histopathological parameters

BARONETTI JL; CHIAPELLO LS; AOKI MP; GEA S; MASIH DT

MEDICAL MYCOLOGY

Año: 2006 vol. 44 p. 493 - 493

1369-3786

span lang="en" style="FONT-FAMILY: "Times New Roman"; FONT-SIZE: 12pt; mso-fareast-font-family: "Times New Roman"; mso-ansi-language: EN-US; mso-fareast-language: ES; mso-bidi-language: AR-SA">Immune response, including protection and cell-mediated immune (CMI) response were evaluated in a  model of disseminated cryptococcosis in rats. In order to study  this parameters, we have established two immunization protocols, immunization with heat killed cells (HKC) of Cryptococcus neoformans and capsular polysaccharide (CPS)  emulsified in complete Freund adjuvant (CFA), four days prior to infection with Cryptococcus neoformans. Rats immunized with HKC-CFA and intraperitoneally infected with